Therapeutic use of oxytocin should include sex as a factor in determining dose regimens. These findings are consistent with the notion that oxytocin regulates many of the same behaviors in males and females, but that the effects are typically more profound in females. However, females were more sensitive to lower doses of oxytocin than males. In general, oxytocin had similar effects in both sexes. However, sucrose seeking in response to a sucrose prime was only decreased by the highest oxytocin dose in both sexes. Likewise, lower doses of oxytocin in females decreased responding for sucrose during maintenance of sucrose self-administration and reinstatement to sucrose-conditioned cues. Lower doses of oxytocin decreased motor activity in a novel environment in females relative to males. Male and freely cycling female rats received vehicle or oxytocin (0.1, 0.3, 1, 3mg/kg, IP) injections before behavioral tests designed to assess general motor activity, as well as sucrose self-administration and seeking. Here, we determined whether male and female rats would show similar dose response curves in response to acute oxytocin on measures of locomotor activity, sucrose seeking, and sucrose intake. While the role of oxytocin in pair bonding and reproduction has been extensively studied, sex differences in conditioned and unconditioned behavioral responses to oxytocin treatment have not been fully characterized. Oxytocin has a modulatory role in natural and drug reward processes. Zhou, Luyi Ghee, Shannon M See, Ronald E Reichel, Carmela M Oxytocin differentially affects sucrose taking and seeking in male and female rats. Thirty-one males with Autism spectrum disorder (ASD) and thirty healthy males participated in a double-blind placebo-controlled crossover trial. The study investigated whether baseline plasma oxytocin (OXT) concentrations might moderate the effects of nasally administered OXT on social orienting. Noltes, Henriette Tucha, Oliver Sweep, Fred C. Do blood plasma levels of oxytocin moderate the effect of nasally administered oxytocin on social orienting in high-functioning male adults with autism spectrum disorder?Īlthaus, Monika Groen, Yvonne Wijers, Albertus A.

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